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Alginate micro-bead fabrication on a centrifugal microfluidics platform

机译:在离心微流控平台上制备藻酸盐微珠

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摘要

We present a novel method for the direct, centrifugally induced fabrication of small alginate beads displaying adjustable diameters between 180 mum and 800 mum by polymer-tube micronozzles. The size distribution features a CV of 7 - 16 % for the main peak. Up to 600 beads per second and channel are issued from the micronozzle through an air gap towards a standard lab tube ("Eppi") attached to the rotor spinning and containing a curing agent. At spinning frequencies between 5 Hz and 28 Hz, the tubes align horizontally under rotation and return to a vertical position as soon as the rotor is at rest. The hardened beads are collected within the tube for further processing or characterization. This method is considered as a low cost technology for micro encapsulation technologies.
机译:我们提出了一种新的方法,用于直接,离心诱导的小藻酸盐珠的制造,该藻酸盐珠通过聚合物管微喷嘴显示直径在180微米至800微米之间的可调直径。大小分布的主峰CV为7-16%。每秒最多600个珠子和通道从微喷嘴通过气隙向连接到转子纺丝并包含固化剂的标准实验室管(“ Eppi”)发出。在5 Hz和28 Hz之间的旋转频率下,这些管在旋转时会水平对齐,并在转子静止后立即返回到垂直位置。硬化的珠粒收集在试管内,以进行进一步处理或表征。该方法被认为是微封装技术的低成本技术。

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